What does this research mean for the field?

There are at least three distinct antigenic areas on the surface of the foot-and-mouth disease virus involved in neutralization, with one specific site responsible for interaction with cellular receptor sites on susceptible cells. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

August 1, 1984Journal of VirologyOpen Access

Epitopes on foot-and-mouth disease virus outer capsid protein VP1 involved in neutralization and cell attachment

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Population

Foot-and-mouth disease virus type A12 and cultured cells

Design

Preclinical

Authors

BBBarry BaxtAgricultural Research Service DMD.O. MorganUnited States Department of Agriculture BRBetty H. RobertsonCedars-Sinai Medical Center

Discussion

Member takes

Implication

Identifies variable FMDV adsorption inhibition; leaves open epitope-targeted vaccine design pending livestock validation.

Structured PICO

Population

Foot-and-mouth disease virus type A12 and cultured cells

Intervention

Monoclonal antibodies prepared against type A12 virus, isolated A12 VP1, and a CNBr-generated A12 VP1 fragment

Outcome

Neutralization of viral infectivity and effect on viral absorption/attachment to cellssurrogate

The study identifies at least three antigenic areas on the foot-and-mouth disease virus VP1 protein involved in neutralization, including one responsible for cellular receptor interaction.

Cite This Study

Baxt et al. (1984) studied this question.

synapsesocial.com/papers/6a18b577d654b1eb0d4ace29 https://doi.org/10.1128/jvi.51.2.298-305.1984

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August 1, 1984Journal of VirologyOpen Access

Epitopes on foot-and-mouth disease virus outer capsid protein VP1 involved in neutralization and cell attachment

View Full Paper

Ask AI

Bookmark

Population

Foot-and-mouth disease virus type A12 and cultured cells

Design

Preclinical

Authors

BBBarry BaxtAgricultural Research Service DMD.O. MorganUnited States Department of Agriculture BRBetty H. RobertsonCedars-Sinai Medical Center

Discussion

Member takes

Implication

Identifies variable FMDV adsorption inhibition; leaves open epitope-targeted vaccine design pending livestock validation.

Structured PICO

Population

Foot-and-mouth disease virus type A12 and cultured cells

Intervention

Monoclonal antibodies prepared against type A12 virus, isolated A12 VP1, and a CNBr-generated A12 VP1 fragment

Outcome

Neutralization of viral infectivity and effect on viral absorption/attachment to cellssurrogate

The study identifies at least three antigenic areas on the foot-and-mouth disease virus VP1 protein involved in neutralization, including one responsible for cellular receptor interaction.

Cite This Study

Baxt et al. (1984) studied this question.

synapsesocial.com/papers/6a18b577d654b1eb0d4ace29 https://doi.org/10.1128/jvi.51.2.298-305.1984

Also Consider

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