May 1, 1983Journal of General Virology

The Main Antigenic Determinant Detected by Neutralizing Monoclonal Antibodies on the Intact Foot-and-Mouth Disease Virus Particle is Absent from Isolated VP1

View Full Paper

Ask AI

Bookmark

Population

Intact foot-and-mouth disease virus type O1 particles, trypsin-treated virus particles, 12S subunit, and…

Design

Preclinical

Authors

RMRob H. MeloenPepscan (Netherlands)JBJ BriaireTuBerculosis Vaccine Initiative RWR WoortmeyerVeterinary Research Institute

Discussion

Member takes

Implication

Neutralizing epitopes on FMDV require native particle conformation; leaves open whether VP1 subunits can elicit protective immunity.

Structured PICO

Population

Intact foot-and-mouth disease virus type O1 particles, trypsin-treated virus particles, 12S subunit, and isolated capsid protein VP1

Intervention

Neutralizing monoclonal antibodies raised against intact foot-and-mouth disease virus type O1

Outcome

Reactivity of neutralizing monoclonal antibodies with different viral componentssurrogate

The neutralizing antigenic determinants on intact foot-and-mouth disease virus particles differ from those on isolated capsid protein VP1, suggesting the neutralizing determinant and cell attachment site are not identical.

Cite This Study

Meloen et al. (1983) studied this question.

synapsesocial.com/papers/6a6f56d02163a0a01bc3a6bd https://doi.org/10.1099/0022-1317-64-5-1193

View Full Paper

Ask AI

Bookmark

The Main Antigenic Determinant Detected by Neutralizing Monoclonal Antibodies on the Intact Foot-and-Mouth Disease Virus Particle is Absent from Isolated VP1

Discussion

Member takes

Implication

Structured PICO

Cite This Study

The Main Antigenic Determinant Detected by Neutralizing Monoclonal Antibodies on the Intact Foot-and-Mouth Disease Virus Particle is Absent from Isolated VP1

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider