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September 1, 1984Journal of General Virology

Localization of a Neutralization Epitope of Foot-and-Mouth Disease Virus Using Neutralizing Monoclonal Antibodies

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Population

Foot-and-mouth disease virus (intact particles and isolated VP1 from different strains)

Design

Preclinical

Authors

MDMarie‐Josèphe DuchesneInsermTCTerence CartwrightZoological Society of LondonACAndré Luiz Barreto CrespoCorteva (United States)

Discussion

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Implication

Defines protease-sensitive neutralization epitope on FMDV VP1; leaves open its utility for vaccine or diagnostic design.

Structured PICO

P
Population
Foot-and-mouth disease virus (intact particles and isolated VP1 from different strains)
I
Intervention
Neutralizing monoclonal antibodies; treatment with trypsin or arginine-specific protease; synthetic peptide analogue
O
Outcome
Recognition/reactivity of the virus and VP1 by neutralizing antibodiessurrogate

The study identifies a neutralization epitope in the central region of VP1 of the foot-and-mouth disease virus that is cleaved by trypsin and arginine-specific protease.

Cite This Study

Duchesne et al. (1984) studied this question.

synapsesocial.com/papers/6a7065cfac440176ef291063https://doi.org/10.1099/0022-1317-65-9-1559
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Demonstration of Neutralizing and Non-neutralizing Epitopes on the Trypsin-sensitive Site of Foot-and-Mouth Disease Virus1984 · 26 citations
  2. 2The Main Antigenic Determinant Detected by Neutralizing Monoclonal Antibodies on the Intact Foot-and-Mouth Disease Virus Particle is Absent from Isolated VP11983 · 39 citations
  3. 3Identification of an exposed region of the immunogenic capsid polypeptide VP1 on foot-and-mouth disease virus1983 · 45 citations
  4. 4Location and Characterization of the Antigenic Portion of the FMDV Immunizing Protein1982 · 367 citations
  5. 5Immune and Antibody Responses to an Isolated Capsid Protein of Foot-and-Mouth Disease Virus1975 · 216 citations