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January 1, 1984Journal of General Virology

Demonstration of Neutralizing and Non-neutralizing Epitopes on the Trypsin-sensitive Site of Foot-and-Mouth Disease Virus

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Population

Foot-and-mouth disease virus (FMDV) 140S and 12S particles

Design

Preclinical

Authors

EOE. J. OuldridgePBPhil BarnettNPN. R. Parry

Discussion

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Overview

May guide FMDV vaccine antigen selection; leaves open in vivo protective efficacy.

Structured PICO

P
Population
Foot-and-mouth disease virus (FMDV) 140S and 12S particles
I
Intervention
Monoclonal antibodies directed against the trypsin-sensitive site
O
Outcome
Demonstration of distinct epitopes and virus neutralizationsurrogate

Monoclonal antibodies identified at least three distinct epitopes on the trypsin-sensitive site of FMDV 140S particles, with two mediating virus neutralization.

Cite This Study

Ouldridge et al. (1984) studied this question.

synapsesocial.com/papers/6a6f56d02163a0a01bc3a6bbhttps://doi.org/10.1099/0022-1317-65-1-203
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Main Antigenic Determinant Detected by Neutralizing Monoclonal Antibodies on the Intact Foot-and-Mouth Disease Virus Particle is Absent from Isolated VP11983 · 39 citations
  2. 2Comparison of the Antibodies Elicited by the Individual Structural Polypeptides of Foot-and-Mouth Disease and Polio Viruses1979 · 87 citations
  3. 3A Study of the Cross-reacting Antigens on the Intact Foot-and-Mouth Disease Virus and its 12S Subunits with Antisera Against the Structural Proteins1980 · 47 citations
  4. 4Location and Characterization of the Antigenic Portion of the FMDV Immunizing Protein1982 · 367 citations
  5. 5Nature of the Antibody Response to the Foot-and-Mouth Disease Virus Particle, its 12S Protein Subunit and the Isolated Immunizing Polypeptide VP11982 · 27 citations