August 1, 1981Journal of General Virology

Neutralization of Foot-and-Mouth Disease Virus. I. Sensitization of the 140S Virion by Antibody Also Reactive with the 12S Protein Subunit

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Population

In vitro foot-and-mouth disease virus (FMDV) preparations

Design

Preclinical

Authors

MHM. M. HardyPlum Island Animal Disease Center DMD. M. MooreUniversity of Florida

Discussion

Member takes

Implication

May inform FMDV vaccine epitope selection; leaves open in vivo validation in livestock.

Structured PICO

Population

In vitro foot-and-mouth disease virus (FMDV) preparations

Intervention

Immune serum and immunoabsorbent fractionated antibodies (140S virion-specific and 12S subunit cross-reactive)

Outcome

Virus neutralizationsurrogate

Demonstrates that antibody specificity to the 140S virion versus the 12S subunit determines the effectiveness of foot-and-mouth disease virus neutralization in vitro.

Cite This Study

Hardy et al. (1981) studied this question.

synapsesocial.com/papers/6a6f5643ac440176ef280783 https://doi.org/10.1099/0022-1317-55-2-415

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