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February 1, 1987Journal of General Virology

Antigenicity and Immunogenicity of Synthetic Peptides of Foot-and-Mouth Disease Virus

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Population

Synthetic peptides of foot-and-mouth disease virus A10 outer structural viral protein VP1

Design

Preclinical

Authors

RMRob H. MeloenWPW. C. PuykDMde Meijer

Discussion

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Overview

Highlights minimal FMDV epitopes for mAb binding; hypothesis-generating and requires in vivo protection studies.

Structured PICO

P
Population
Synthetic peptides of foot-and-mouth disease virus A10 outer structural viral protein VP1
I
Intervention
Binding with neutralizing monoclonal antibodies
O
Outcome
Antigenicity and immunogenicity (ability to bind monoclonal antibody and induce neutralizing activity)surrogate

The study identifies specific amino acids within synthetic peptides of foot-and-mouth disease virus that are critical for antibody binding and neutralizing activity.

Cite This Study

Meloen et al. (1987) studied this question.

synapsesocial.com/papers/6a2395149e1c90a91c08ee73https://doi.org/10.1099/0022-1317-68-2-305
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Small peptides induce antibodies with a sequence and structural requirement for binding antigen comparable to antibodies raised against the native protein.1985 · 289 citations
  2. 2The Main Antigenic Determinant Detected by Neutralizing Monoclonal Antibodies on the Intact Foot-and-Mouth Disease Virus Particle is Absent from Isolated VP11983 · 39 citations
  3. 3An Epitope Located at the C Terminus of Isolated VP1 of Foot-and-Mouth Disease Virus Type O Induces Neutralizing Activity but Poor Protection1986 · 28 citations
  4. 4A Study of the Cross-reacting Antigens on the Intact Foot-and-Mouth Disease Virus and its 12S Subunits with Antisera Against the Structural Proteins1980 · 47 citations
  5. 5Antigenic Variation and Resistance to Neutralization in Poliovirus Type 11985 · 126 citations