Key result
Dinitrophenyl protection yields better synthetic foot-and-mouth disease virus peptides for monoclonal antibody testing.
Population
Synthetic peptides representing the immunodominant loop of foot-and-mouth disease virus strain C-S8 and…
Comparison
Synthesis of peptides with single-residue… vs Wild-type peptide sequence and Tosyl protection…
Design
Preclinical
Authors
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Dinitrophenyl protection may optimize FMDV peptide synthesis; leaves open translation to antigenic or vaccine applications.
Dinitrophenyl protection improves the synthesis of FMDV VP1 loop peptides, which can be used to study antigenic variability via monoclonal antibody reactivity.
Carreño et al. (1992) studied Foot-and-mouth disease virus. Synthetic peptides was evaluated on Immunochemical reactivity in an immunodot assay. Synthetic peptides representing the VP1 loop of foot-and-mouth disease virus were synthesized and tested against monoclonal antibodies, with dinitrophenyl protection yielding better synthetic products.
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