Peptides 135-159 and 170-189 of the VP1 protein of foot-and-mouth disease virus strain A22 contain virus-specific T-cell recognition sites.
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Candidate FMDV VP1 epitopes identified in animals; leaves open validation for vaccine development in livestock.
Immunogenicity studies of synthetic peptides from different regions of VP1 protein of foot-and-mouth disease virus strain A22 revealed the following active fragments: 39-61, 50-69, 135-159, 175-189, 170-189 and 197-213. Testing of virus neutralizing antibody production in rabbits primed by peptides and then inoculated by the virus showed that only peptides 135-159 and 170-189 were able to induce the functional T-cell helper activity. Localization of virus-specific T-cell recognition sites in sequences 135-159 and 170-189 was confirmed in in vitro recognition experiments of the virus by peptide activated mice lymphocytes.
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Volpina et al. (1993) studied this question.
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