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October 25, 1993FEBS LettersOpen Access

New virus‐specific T‐helper epitopes of foot‐and‐mouth disease viral VP1 protein

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Population

Rabbits and mice (lymphocytes) used for immunogenicity studies of foot-and-mouth disease virus strain A22

Design

Preclinical

Authors

OVO. M. VolpinaVGVasily M. GelfanovAYAleksey V. Yarov

Discussion

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Overview

Candidate FMDV VP1 epitopes identified in animals; leaves open validation for vaccine development in livestock.

Structured PICO

P
Population
Rabbits and mice (lymphocytes) used for immunogenicity studies of foot-and-mouth disease virus strain A22
I
Intervention
Priming with synthetic peptides from VP1 protein (fragments 39-61, 50-69, 135-159, 175-189, 170-189 and 197-213) followed by virus inoculation
O
Outcome
Virus neutralizing antibody production and functional T-cell helper activitysurrogate

Peptides 135-159 and 170-189 of the VP1 protein of foot-and-mouth disease virus strain A22 contain virus-specific T-cell recognition sites.

Cite This Study

Volpina et al. (1993) studied this question.

synapsesocial.com/papers/6a7065d3febe604dd7092f21https://doi.org/10.1016/0014-5793(93)80399-f
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Antigenicity and Immunogenicity of Synthetic Peptides of Foot-and-Mouth Disease Virus1987 · 59 citations
  2. 2A T cell epitope in VP1 of foot-and-mouth disease virus is immunodominant for vaccinated cattle1991 · 131 citations
  3. 3Comparison of the amino acid sequence of the major immunogen from three serotypes of foot and mouth disease virus1982 · 87 citations
  4. 4Identification of an exposed region of the immunogenic capsid polypeptide VP1 on foot-and-mouth disease virus1983 · 45 citations
  5. 5Use of peptide synthesis to probe viral antigens for epitopes to a resolution of a single amino acid.1984 · 1,481 citations