May 2, 1986Science

Protection of Cattle Against Foot-and-Mouth Disease by a Synthetic Peptide

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Population

Cattle and guinea pigs

Comparison

Chemically synthesized peptide consisting of two… vs Single-site peptide evaluated in guinea pigs

Design

Preclinical

Authors

RDRichard D. DiMarchiNovo Nordisk (United States)GBGerald S. BrookeEli Lilly (United States)CGCharles GaleKarolinska University Hospital

Discussion

Member takes

Implication

Peptide protects cattle in challenge model; leaves open field efficacy and durability of VP1-based FMD vaccines.

Structured PICO

Population

Cattle and guinea pigs

Intervention

Chemically synthesized peptide consisting of two separate regions (residues 141 to 158 and 200 to 213) of a virus coat protein (VP1) from the O1 Kaufbeuren strain of foot-and-mouth disease virus, prepared free of any carrier protein

Comparator

Single-site peptide (residues 141 to 158) evaluated in guinea pigs

Outcome

Neutralizing antibody levels and protection against intradermolingual challenge by inoculation with infectious virussurrogate

A synthetic peptide containing two regions of the VP1 coat protein can elicit neutralizing antibodies and protect cattle against foot-and-mouth disease.

Cite This Study

DiMarchi et al. (1986) studied this question.

synapsesocial.com/papers/6a706557e5469ee92be12317 https://doi.org/10.1126/science.3008333

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Protection of Cattle Against Foot-and-Mouth Disease by a Synthetic Peptide

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Protection of Cattle Against Foot-and-Mouth Disease by a Synthetic Peptide

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider