Key result
Dendrimeric peptides B2T and B4T elicited specific humoral responses in cattle and conferred partial protection against challenge with a heterologous type O foot-and-mouth disease virus.
May guide veterinary FMD vaccine strategies; leaves open confirmation in larger randomized field trials.
Synthetic peptides mimicking protective B- and T-cell epitopes are good candidates for safer, more effective FMD vaccines. Nevertheless, previous studies of immunization with linear peptides showed that they failed to induce solid protection in cattle. Dendrimeric peptides displaying two or four copies of a peptide corresponding to the B-cell epitope VP1 [136–154] of type O FMDV (O/UKG/11/2001) linked through thioether bonds to a single copy of the T-cell epitope 3A [21–35] (termed B 2 T and B 4 T, resp.) afforded protection in vaccinated pigs. In this work, we show that dendrimeric peptides B 2 T and B 4 T can elicit specific humoral responses in cattle and confer partial protection against the challenge with a heterologous type O virus (O1/Campos/Bra/58). This protective response correlated with the induction of specific T-cells as well as with an anamnestic antibody response upon virus challenge, as shown by the detection of virus-specific antibody-secreting cells (ASC) in lymphoid tissues distal from the inoculation point.
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Soria et al. (2018) studied Foot-and-Mouth Disease. Dendrimeric peptides B2T and B4T was evaluated on Humoral response and protection against heterologous type O virus challenge. Dendrimeric peptides B2T and B4T elicited specific humoral responses in cattle and conferred partial protection against challenge with a heterologous type O foot-and-mouth disease virus.
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