March 1, 1990Journal of General Virology

A single amino acid substitution affects multiple overlapping epitopes in the major antigenic site of foot-and-mouth disease virus of serotype C

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Population

Foot-and-mouth disease virus (FMDV) of serotype C, field isolates, variant FMDVs, and synthetic peptides

Design

Preclinical

Authors

MMMauricio G. MateuCentro de Biología Molecular Severo Ochoa MMMiguel Ángel Martı́nezUniversitat Autònoma de Barcelona LCLorenzo CapucciIstituto Zooprofilattico Sperimentale della Lombardia e dell'Emilia Romagna "Bruno Ubertini"

Discussion

Member takes

Implication

Hypothesis-generating for FMDV antigenic escape; requires validation in field isolates before guiding vaccine updates.

Structured PICO

Population

Foot-and-mouth disease virus (FMDV) of serotype C, field isolates, variant FMDVs, and synthetic peptides

Intervention

Neutralizing monoclonal antibodies (nMAbs) elicited against FMDV serotype C

Outcome

Reactivity of nMAbs with synthetic peptides and nMAb-resistant mutantssurrogate

A single amino acid substitution in the main antigenic site of FMDV serotype C can abolish reactivity with multiple neutralizing monoclonal antibodies, demonstrating a highly amplified phenotypic effect from a minimal genetic change.

Cite This Study

Mateu et al. (1990) studied this question.

synapsesocial.com/papers/6a705090a2d7cf2e39c2a5f1 https://doi.org/10.1099/0022-1317-71-3-629

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A single amino acid substitution affects multiple overlapping epitopes in the major antigenic site of foot-and-mouth disease virus of serotype C

Discussion

Member takes

Implication

Structured PICO

Cite This Study

A single amino acid substitution affects multiple overlapping epitopes in the major antigenic site of foot-and-mouth disease virus of serotype C

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider