The study demonstrates differences in the neutralizing antibody response elicited by individual structural polypeptides of foot-and-mouth disease virus compared to poliovirus.
Answers are grounded in this paper and cite their sources.
Animal data show VP1 elicits neutralizing antibodies in FMDV unlike poliovirus polypeptides; leaves open implications for picornavirus vaccine design.
Antibody produced against preparations of VP1, one of the four structural polypeptides of foot-and-mouth disease virus, neutralized the virus and reacted with both full and empty particles in radioimmunoassays (RIA). Antiserum against VP2 reacted with artificial empty particles of the virus but not with full particles. In contrast, none of the individual polypeptides of poliovirus produced antisera which neutralized the virus nor reacted with it in RIA. However, antisera produced with VP1 and VP2 reacted with artificial empty particles in RIA.
No takes yet. Share an insight, caveat, or question.
Meloen et al. (1979) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: