Key result
Lower preoperative hemoglobin in women is linked to ~49% higher AKI odds per 1 g/dL drop.
Why the study?
Preoperative anemia is common in cardiac surgery, but limited data described the role of sex in associations between anemia and clinical outcomes to guide preoperative optimization.
Does preoperative anemia increase the risk of postoperative acute kidney injury and other adverse outcomes in adults undergoing elective cardiac surgery?
Cohort (n=4,117)
No
Does preoperative anemia increase the risk of postoperative acute kidney injury and other adverse outcomes in adults undergoing elective cardiac surgery?
Odds Ratio: 1.49 (95% CI 1.23–1.81)
p-value: p=<0.001
Preoperative anemia is associated with inferior clinical outcomes after cardiac surgery, with distinct hemoglobin thresholds and risk profiles for men and women.
No takes yet. Share an insight, caveat, or question.
Sex-specific hemoglobin thresholds may guide preoperative AKI risk assessment in cardiac surgery; leaves open whether anemia correction reduces events in women.
Ripoll et al. (2021) conducted a cohort in Adults undergoing elective cardiac surgery (n=4,117). Preoperative hemoglobin concentration vs. Higher preoperative hemoglobin concentration was evaluated on Postoperative acute kidney injury (AKI) within 7 days of ICU admission (OR 1.49, 95% CI 1.23-1.81, p=<0.001). In women, each 1 g/dL decrease in preoperative hemoglobin below 13 g/dL was associated with increased odds of acute kidney injury (OR 1.49), whereas the association in men was not statistically significant.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: