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INTRODUCTION: cells in cancer immunity and responses to ICIs in GC remain poorly understood. OBJECTIVES: cells by PVR/TIGIT axis to facilitate immune evasion. METHODS: The immune status of GC was evaluated by quantifying T cell subsets in GC tissues through flow cytometry. The biological functions and molecular mechanisms by which the oncogenic factor PRDM15 mediates tumor immune evasion were investigated through the PVR/TIGIT axis using transcriptome sequencing, Chromatin immunoprecipitation (ChIP) assay and Co-immunoprecipitation assay. The therapeutic potential of PRDM15/PVR/TIGIT was analyzed using tumor-bearing models. RESULTS: cells activation by upregulating PVR expression in GC cells. Mechanistically, PRDM15 recruited the histone methyltransferase complex PRMT5/Mep50/WDR5 to activate PVR transcription. CONCLUSION: cells activation and mediates immune escape and GC progression.
Zhang et al. (Sat,) studied this question.