What question did this study set out to answer?

To quantify intermediolateral column neurons in the thoracic spinal cord of patients with motor neuron disease and Shy-Drager syndrome relative to control tissue.

November 1, 1985ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam)Open Access

A quantitative study of intermediolateral column cells in motor neuron disease and the Shy-Drager syndrome.

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Authors

PKPeter G. E. KennedyUniversity of Glasgow LDL. W. DuchenNational Hospital for Neurology and Neurosurgery

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Implication

Post-mortem study reveals significant spinal sympathetic cell loss in Shy-Drager syndrome but not motor neuron disease, highlighting distinct autonomic involvement.

Key Points

To quantify intermediolateral column neurons in the thoracic spinal cord of patients with motor neuron disease and Shy-Drager syndrome relative to control tissue.
Counted neurons in the intermediolateral column of the thoracic spinal cord lateral horns post-mortem in five patients with motor neuron disease, two with Shy-Drager syndrome, and three neurological controls without spinal cord involvement.
Assessed cell numbers across the total thoracic sympathetic outflow as well as separately within the upper, middle, and lower thirds of the thoracic cord.
Motor neuron disease specimens showed a slight reduction in intermediolateral column cells across the entire thoracic sympathetic outflow and each third, but the difference was not statistically significant.
Shy-Drager syndrome specimens demonstrated a highly significant reduction in intermediolateral column neurons compared to control spinal cords.

Cite This Study

Kennedy et al. (1985) studied this question.

synapsesocial.com/papers/6a1d7b78659691eef004ce4d https://doi.org/10.1136/jnnp.48.11.1103

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Implication

Post-mortem study reveals significant spinal sympathetic cell loss in Shy-Drager syndrome but not motor neuron disease, highlighting distinct autonomic involvement.

A quantitative study of intermediolateral column cells in motor neuron disease and the Shy-Drager syndrome.

Discussion

Member takes

Implication

Key Points

Cite This Study

A quantitative study of intermediolateral column cells in motor neuron disease and the Shy-Drager syndrome.

Discussion

Member takes

Implication

Key Points

Cite This Study

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