What question did this study set out to answer?

To review how gastrointestinal microbes process dietary and host substrates to generate local and systemic metabolites that influence human health and disease.

October 17, 2019Annual Review of Pathology Mechanisms of DiseaseOpen Access

Microbial Contribution to the Human Metabolome: Implications for Health and Disease

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Authors

WTWilliam Van TreurenStanford University DDDylan DoddStanford Medicine

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Implication

Review uncovers microbial metabolic contributions to local and circulating metabolomes in humans, suggesting novel therapeutic targets for personalized medicine.

Key Points

To review how gastrointestinal microbes process dietary and host substrates to generate local and systemic metabolites that influence human health and disease.
Narrative synthesis of mechanisms underlying anaerobic microbial energy capture and substrate fermentation in the human gastrointestinal tract.
Analysis of pathways through which microbiota-derived metabolites accumulate locally or enter systemic circulation to alter host physiology.
Gastrointestinal microbes produce extensive repertoires of bioactive metabolites that act directly on intestinal cells or circulate to affect distal organs.
Dietary intake and individual microbiome diversity drive pronounced inter-individual variation in circulating microbial metabolite profiles.
Targeted modulation of microbial metabolic output offers promising pathways for designing personalized therapeutic interventions.

Cite This Study

Treuren et al. (2019) studied this question.

synapsesocial.com/papers/6a1d7c4f7328fa9a742f9203 https://doi.org/10.1146/annurev-pathol-020117-043559

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Implication

Review uncovers microbial metabolic contributions to local and circulating metabolomes in humans, suggesting novel therapeutic targets for personalized medicine.

Microbial Contribution to the Human Metabolome: Implications for Health and Disease

Discussion

Member takes

Implication

Key Points

Cite This Study

Microbial Contribution to the Human Metabolome: Implications for Health and Disease

Discussion

Member takes

Implication

Key Points

Cite This Study

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