Key result
In healthy male subjects aged 30 to 79 years, increasing age was significantly associated with prolonged basal Tp-e intervals and decreased heart rate variability temporal parameters.
Why the study?
Heart rate variability predicts cardiac autonomic function and ventricular repolarization markers can indicate ventricular arrhythmias, but their variations across age decades in healthy men required evaluation.
Cross-Sectional (n=500)
In healthy men, normal aging is associated with a significant increase in the Tp-e interval and a decrease in temporal heart rate variability, reflecting age-related changes in ventricular repolarization and autonomic function.
Answers are grounded in this paper and cite their sources.
These associations in healthy men warrant no practice change; leaves open prospective arrhythmia risk prediction.
BACKGROUND: Heart rate variability (HRV) is a predictor of cardiac autonomic functions. Ventricular repolarization markers can indicate ventricular arrhythmias. We aimed to evaluate variations of HRV and these repolarization markers in five healthy male groups between age 30 and 79 years according to decades. MATERIALS AND METHODS: The study group consisted of 500 healthy male subjects between October 2018 and May 2019. The male subjects were divided into five categories according to their ages. Then, electrocardiograms (ECG), transthoracic echocardiograms (TTE), and treadmill exercise test (TET) were performed. T-wave peak-end (Tp-e) interval was defined as the time between the peak point and end of T-wave. Tp-e, corrected Tp-e (cTp-e), QT, and corrected QT (QTc) were measured from the resting ECGs and HRV temporal parameters (SDNN, SDNN Index, SDANN Index, RMSSD, sNN50, and pNN50), and HRV frequency parameters (VLF, LF, HF, and LF/HF) were obtained from 24-hour Holter monitorization recordings. One-way ANOVA test was used for the differences between the groups. Pearson correlation test was used to determine the correlations between the values of all groups. RESULTS: Considering the repolarization parameters, there are significant differences in five groups in terms of Tp-e interval, but not Tp-e/QT and Tp-e/QTc ratios. Considering the HRV parameters, there were statistically significant differences between the five male healthy groups in terms of HRV temporal parameters and there are no significant differences in terms of HRV frequency parameters. CONCLUSION: As the age increases, basal Tp-e interval increases and HRV temporal parameters decrease significantly in the male subjects aged between 30 and 79 years, but HRV frequency parameters do not change.
No takes yet. Share an insight, caveat, or question.
Coşgun et al. (2020) conducted a cross-sectional in Healthy (n=500). Age (decades) vs. Younger age decades was evaluated on Tp-e interval and HRV temporal parameters (p=<0.0025). In healthy male subjects aged 30 to 79 years, increasing age was significantly associated with prolonged basal Tp-e intervals and decreased heart rate variability temporal parameters.
Synapse has enriched 10 related papers. Consider them for comparative context: