January 1, 2003Pacing and Clinical Electrophysiology

Circadian Profile of QT Interval and QT Interval Variability in 172 Healthy Volunteers

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Population

172 healthy subjects who were fully active, awoke at approximately 7:00 AM, and had 6-8 hours of sleep.

Design

Cross-sectional

Follow-up

24 hours

Authors

HBHendrik BonnemeierKiel University UWUwe WiegandSana Klinikum WBWIEBKE BRAASCHUniversity of Lübeck

Discussion

Member takes

Implication

Morning QT variability rise may flag arrhythmic vulnerability; leaves open whether sympathetic modulation alters outcomes.

Structured PICO

Population

172 healthy subjects (89 women, 83 men; mean age 38.7 +/- 15 years) who were fully active, awoke at approximately 7:00 AM, and had 6-8 hours of sleep.

Intervention

24-hour ambulatory electrocardiogram monitoring

Outcome

Beat-to-beat QT interval duration (QT, QTapex [QTa], Tend [Te]), variability (QTSD, QTaSD), and the mean R-R intervalsurrogate

QT interval variability exhibits a significant morning increase, suggesting a relationship with cardiac sympathetic activity and the known diurnal pattern of malignant ventricular arrhythmias.

Cite This Study

Bonnemeier et al. (2003) studied this question.

synapsesocial.com/papers/6a1bcf8d26cb5670aa9cf000 https://doi.org/10.1046/j.1460-9592.2003.00053.x

View Full Paper

Ask AI

Bookmark

Circadian Profile of QT Interval and QT Interval Variability in 172 Healthy Volunteers

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Circadian Profile of QT Interval and QT Interval Variability in 172 Healthy Volunteers

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider