Key result
Exercise training can control pathological cardiac hypertrophy associated with middle-age and inactivity, though it may lead to physiological hypertrophy.
Why the study?
Does exercise training affect the development of pathological versus physiological cardiac hypertrophy in middle-aged individuals?
Does exercise training affect the development of pathological versus physiological cardiac hypertrophy in middle-aged individuals?
This review highlights that while aging and inactivity promote pathological cardiac hypertrophy, exercise training can mitigate this risk while potentially inducing physiological hypertrophy.
May support exercise to mitigate pathological hypertrophy in middle-aged inactivity; hypothesis-generating, leaves open need for prospective trials.
: Aging is an inevitable process, which is associated with the development of various diseases such as cardiac hypertrophy. Hypertrophy can occur in both pathological and physiological types. Both types can be divided into eccentric or concentric. If age is associated with inactivity, this can lead to pathological heart hypertrophy. However, exercise is able to control pathological hypertrophy, but it could lead to physiological hypertrophy. In this paper, we consider the effects of middle-age on heart and cardiac hypertrophy types and the effects of exercise.
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Baghaiee et al. (2018) conducted a review in Cardiac hypertrophy. Exercise training vs. Inactivity was evaluated. Exercise training can control pathological cardiac hypertrophy associated with middle-age and inactivity, though it may lead to physiological hypertrophy.
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