Key result
Beetroot extract and resveratrol fail to improve post-exercise heart rate recovery in CVD patients.
Why the study?
Postexercise recovery is a crucial period associated with increased cardiac risk in cardiovascular disease, prompting investigation into whether beetroot extract and resveratrol confer cardioprotection.
Does beetroot extract and/or resveratrol improve immediate postexercise recovery in patients with coronary artery disease?
RCT
Crossover
Does beetroot extract and/or resveratrol improve immediate postexercise recovery in patients with coronary artery disease?
p-value: p=0.719
Supplementation with beetroot extract and/or resveratrol before exercise does not significantly improve immediate post-exercise heart rate recovery, heart rate variability, or blood pressure in patients with coronary artery disease.
No support for pre-exercise beetroot or resveratrol to aid recovery in CVD; challenges their adjunctive role in cardiac rehabilitation.
• Subjects with CVD may have autonomic modulation impairment. • Postexercise recovery crucial for increased cardiac event risk. • Beetroot and resveratrol supplementation explored for cardioprotection. • Study investigates impact of beet extract and resveratrol on CVD recovery. Postexercise recovery is a crucial period, especially in patients with cardiovascular disease (CVD). Supplementation with nutraceutical substances has been explored due to its potential cardioprotective effects. We aimed to investigate the impact of isolated and combined ingestion of beetroot extract and resveratrol on immediate postexercise recovery. Individuals with CVD were subjected to 4 experimental protocols consisting of 30 min of aerobic exercise. Before exercise, the subjects consumed 500 mg of starch, 500 mg of beetroot extract, 500 mg of resveratrol or both substances. Heart rate recovery (HRR), heart rate variability (HRV) and blood pressure (BP) responses were evaluated. No significant differences in the HRR were detected (p = 0.719) in the RMSSD30 index (p = 0.671) or BP responses (systolic BP − p = 0.703, diastolic BP − p = 0.638) between protocols. Supplementation with beetroot extract and/or resveratrol did not promote significant changes in immediate post-exercise recovery. Registration number - clinicaltrials.gov: NCT06095635
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Gonzaga et al. (2024) conducted an RCT in Coronary artery disease. Beetroot extract and/or resveratrol vs. 500 mg of starch was evaluated on Heart rate recovery (HRR) (p=0.719). Supplementation with 500 mg of beetroot extract and/or resveratrol before exercise did not significantly change immediate post-exercise heart rate recovery (p=0.719) in patients with CVD.
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