Resveratrol 10 mg daily for 3 months significantly improved left ventricular diastolic function (p<0.01), endothelial function (p<0.05), and lowered LDL levels (p<0.05) in post-infarction patients.
RCT (n=40)
Double-blind
randomized
Does resveratrol improve left ventricular function, endothelial function, and hemorheological parameters in patients with stable coronary artery disease after myocardial infarction?
Resveratrol supplementation at 10 mg daily for 3 months improves surrogate markers of cardiovascular health, including diastolic function, endothelial function, and LDL cholesterol, in post-myocardial infarction patients.
p-value: p=<0.01
Several beneficial effects of resveratrol (RES), a natural antioxidant present in red wine have already been described. The aim of our study was to investigate if RES had a clinically measurable cardioprotective effect in patients after myocardial infarction. In this double-blind, placebo controlled trial 40 post-infarction Caucasian patients were randomized into two groups. One group received 10 mg RES capsule daily for 3 months. Systolic and diastolic left ventricular function, flow-mediated vasodilation (FMD), several laboratory and hemorheological parameters were measured before and after the treatment. Left ventricular ejection fraction showed an increasing tendency (ns) by RES treatment. However, left ventricular diastolic function was improved significantly (p < 0.01) by RES. A significant improvement in endothelial function measured by FMD was also observed (p < 0.05). Low-density lipoprotein (LDL) level significantly decreased (p < 0.05) in the RES treated group. Red blood cell deformability decreased and platelet aggregation increased significantly in the placebo group (p < 0.05), while resveratrol treatment has prevented these unfavourable changes. Concerning other measured parameters no significant changes were observed neither in placebo nor in RES group. Our results show that resveratrol improved left ventricle diastolic function, endothelial function, lowered LDL-cholesterol level and protected against unfavourable hemorheological changes measured in patients with coronary artery disease (CAD).
Magyar et al. (Sun,) conducted a rct in stable coronary artery disease (n=40). Resveratrol vs. Placebo was evaluated on Left ventricular function, flow-mediated vasodilation, laboratory and hemorheological parameters (p=<0.01). Resveratrol 10 mg daily for 3 months significantly improved left ventricular diastolic function (p<0.01), endothelial function (p<0.05), and lowered LDL levels (p<0.05) in post-infarction patients.