What is the clinical evidence from this study?

Population: Chronic heart failure (n=56). Intervention: Resveratrol vs. Normal diet. Primary outcome: Aortic pulse wave velocity (PWV) (p=<0.05).

December 17, 2016Canadian Journal of Physiology and PharmacologyOpen Access

Long-term low dose dietary resveratrol supplement reduces cardiovascular structural and functional deterioration in chronic heart failure in rats

Q: What are the key findings of this study?

Long-term dietary supplementation with low-dose resveratrol significantly reduced aortic pulse wave velocity and improved left ventricular systolic function compared to a normal diet in rats with chronic heart failure.

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Key result

Long-term dietary supplementation with low-dose resveratrol significantly reduced aortic pulse wave velocity and improved left ventricular systolic function compared to a normal diet in rats with chronic heart failure.

Why the study?

Does long-term low-dose dietary resveratrol reduce cardiovascular structural and functional deterioration in a rat model of chronic heart failure?

Structured PICO

Does long-term low-dose dietary resveratrol reduce cardiovascular structural and functional deterioration in a rat model of chronic heart failure?

Population

56 male Wistar rats with chronic heart failure induced by myocardial infarction (MI size 20-50%) followed for 10 months.

Intervention

Resveratrol-enriched diet (target daily dosage 5 mg/kg per day) for 10 months.

Comparator

Normal diet (Standard NIH rat chow) for 10 months.

Outcome

Cardiovascular structural and functional deterioration (assessed via serial echocardiography for LV ejection fraction, LV volumes, MI expansion, and end-point LV pressure-volume loop analysis and aortic pulse wave velocity).surrogate

Main Result

Absolute Event Rate: 389% vs 489%

p-value: p=<0.05

Long-term, low-dose dietary resveratrol supplementation attenuates cardiovascular structural and functional deterioration in a rat model of chronic heart failure.

Limitations

Animal model (rats) which may not fully translate to human chronic heart failure
Exact mechanism for the beneficial effects of resveratrol remains elusive
Lack of significant effect on accumulated mortality, myocardial infarct expansion, and LV diastolic functional parameters
The exact mechanism for the beneficial effects of resveratrol remains elusive.
The potency of resveratrol against cardiovascular remodeling is less dramatic than reported in studies using high therapeutic dosages.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Should not change HF practice; leaves open translation of resveratrol benefits from rat models to humans.

Cite This Study

Ahmet et al. (2016) studied Chronic heart failure (n=56). Resveratrol vs. Normal diet was evaluated on Aortic pulse wave velocity (PWV) (p=<0.05). Long-term dietary supplementation with low-dose resveratrol significantly reduced aortic pulse wave velocity and improved left ventricular systolic function compared to a normal diet in rats with chronic heart failure.

synapsesocial.com/papers/6a85b9fdbf822e3500c92e5f https://doi.org/10.1139/cjpp-2016-0512

Topics

HFrEF treatment Heart failure Echocardiography

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Long-term low dose dietary resveratrol supplement reduces cardiovascular structural and functional deterioration in chronic heart failure in rats

Structured PICO

Main Result

Limitations

Discussion

Implication

Cite This Study

Topics

Long-term low dose dietary resveratrol supplement reduces cardiovascular structural and functional deterioration in chronic heart failure in rats

Structured PICO

Main Result

Limitations

Discussion

Implication

Cite This Study

Also Consider

Topics

Also Consider