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August 18, 2000Cardiovascular Research

Cardioprotective effect of resveratrol, a natural antioxidant derived from grapes

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Why the study?

Does resveratrol reduce ischemia- and ischemia-reperfusion-induced arrhythmias and mortality in a rat model?

Population

Anesthetized rats subjected to left main coronary artery occlusion for 30 or 5 min followed by a 30-min…

Comparison

Preinfusion with resveratrol before occlusion vs No resveratrol preinfusion

Design

Preclinical

Follow-up

30-min reperfusion

Authors

LHLinda Hung

Discussion

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Overview

Resveratrol attenuates reperfusion arrhythmias in rats; hypothesis-generating and leaves open any clinical translation.

Structured PICO

Does resveratrol reduce ischemia- and ischemia-reperfusion-induced arrhythmias and mortality in a rat model?

P
Population
Anesthetized rats subjected to left main coronary artery occlusion for 30 or 5 min followed by a 30-min reperfusion
I
Intervention
Preinfusion with resveratrol before occlusion
C
Comparator
No resveratrol preinfusion
O
Outcome
Severity of ischemia- and ischemia-reperfusion (I-R)-induced arrhythmias and mortalityhard clinical

Resveratrol demonstrates potent antiarrhythmic and cardioprotective properties against ischemia-reperfusion injury in a rat model, potentially mediated by antioxidant activity and NO upregulation.

Cite This Study

Linda Hung (2000) studied this question.

synapsesocial.com/papers/6a759dfaae41e4ffbd6a3506https://doi.org/10.1016/s0008-6363(00)00102-4
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Reduction of Myocardial Damage and Polymorphonuclear Leukocyte Accumulation Following Coronary Artery Occlusion and Reperfusion by the Thromboxane Receptor Antagonist BM 13.5051989 · 40 citations
  2. 2Exacerbation of reperfusion arrhythmias by sudden oxidant stress.1990 · 32 citations
  3. 3Effect of β-Blockers on Free Radical–Induced Cardiac Contractile Dysfunction1999 · 124 citations
  4. 4Measurement of superoxide-derived free radicals in the reperfused heart. Evidence for a free radical mechanism of reperfusion injury.1988 · 632 citations
  5. 5Myocardial ischaemia: can we agree on a definition for the 21st century?1994 · 112 citations