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[structure: see text] We report G-quartet formation from an N2-modified lipophilic guanosine nucleoside, N2-(4-n-butylphenyl)-2',3',5'-O-triacetylguanosine. We show that, in the presence of either K+ or Na+, this guanosine derivative self-assembles into a D4-symmetric octamer consisting of two stacking all-syn G-quartets in a tail-to-tail (or head-to-head) fashion and a central ion.
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Liu et al. (2006) studied this question.
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