Key result
An ischemic pattern on admission ECG in patients with suspected acute myocardial infarction significantly increased the risk of one-year major adverse cardiac events (HR 2.996).
Why the study?
Fast and accurate risk assessment of chest pain patients remains a clinical challenge, prompting investigation into the prognostic accuracy of admission ECG alone and combined with other clinical variables.
Does the presence of ischemic changes on admission ECG predict major adverse cardiac events in adult patients with chest pain and suspected acute myocardial infarction?
Cohort (n=390)
No
Does the presence of ischemic changes on admission ECG predict major adverse cardiac events in adult patients with chest pain and suspected acute myocardial infarction?
Effect estimate: HR 2.996 (95% CI 1.31-6.86)
Absolute Event Rate: 12% vs 4%
p-value: p=0.009
The presence of ischemic changes on admission ECG, particularly when combined with a single positive high-sensitivity troponin T measurement, strongly predicts one-year major adverse cardiac events in patients presenting with chest pain and suspected AMI.
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Ischemic admission ECG may aid MACE risk stratification in suspected AMI; hypothesis-generating for ECG-troponin integration pending prospective validation.
Muzyk et al. (2023) conducted a cohort in Chest pain with suspicion of acute myocardial infarction (n=390). Ischemic pattern on admission ECG vs. No ischemic changes on admission ECG was evaluated on Major adverse cardiac events (MACE), defined as death, non-fatal myocardial infarction and/or acute revascularization (HR 2.996, 95% CI 1.31-6.86, p=0.009). An ischemic pattern on admission ECG in patients with suspected acute myocardial infarction significantly increased the risk of one-year major adverse cardiac events (HR 2.996).
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