Key result
Pharmacological agents that reduce both blood pressure and proteinuria, particularly ACE inhibitors, significantly slow the rate of progression of chronic kidney disease.
Why the study?
Does antihypertensive therapy, particularly ACE inhibitors, slow the progression of chronic kidney disease?
Population
Patients with chronic kidney disease and hypertension
Comparison
Antihypertensive therapy, particularly… vs Antihypertensive regimens without ACE inhibitors
Design
Review
Authors
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May support ACE inhibitor preference in proteinuric CKD; leaves open prospective RCT confirmation.
Does antihypertensive therapy, particularly ACE inhibitors, slow the progression of chronic kidney disease?
ACE inhibitors provide a renoprotective effect that is additional to their blood pressure and proteinuria lowering effects in patients with chronic kidney disease.
Maschio et al. (2002) conducted a review in Chronic renal disease. ACE inhibitors vs. Antihypertensive regimens without ACE inhibitors was evaluated on Progression of chronic kidney disease. Pharmacological agents that reduce both blood pressure and proteinuria, particularly ACE inhibitors, significantly slow the rate of progression of chronic kidney disease.
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