Key result
MnSOD Ala16Val VV genotype linked to ~87% higher diabetic retinopathy risk in T2D.
Why the study?
The association between the manganese superoxide dismutase (MnSOD) Ala16Val polymorphism and diabetic retinopathy susceptibility in people with type 2 diabetes remains contentious.
Does the MnSOD Ala16Val polymorphism increase the risk of diabetic retinopathy in patients with type 2 diabetes mellitus?
Meta-Analysis (n=2,132)
Does the MnSOD Ala16Val polymorphism increase the risk of diabetic retinopathy in patients with type 2 diabetes mellitus?
Effect estimate: OR 1.87 (95% CI 1.42, 2.46)
p-value: p=<0.0001
The MnSOD Ala16Val genetic polymorphism (specifically the VV allele) is significantly associated with an elevated risk of diabetic retinopathy in individuals with type 2 diabetes, suggesting its potential as a genetic marker for DR susceptibility.
MnSOD VV genotype may flag higher DR risk in T2DM; hypothesis-generating for genetic stratification pending prospective validation.
Background: Diabetic retinopathy (DR) is renowned as a prominent cause of visual impairment worldwide. The association between manganese superoxide dismutase (MnSOD) gene, Ala16Val (rs4880), and DR susceptibility in people with type 2 diabetes mellitus (T2DM) remains contentious. Objective: This meta-analysis aims to evaluate risk of DR in T2DM patients with MnSOD Ala16Val polymorphism. Methods: A literature search was conducted using MEDLINE, Scopus, Web of Science, ScienceDirect, EMBASE, and grey literature to identify potential studies assessing the link between MnSOD polymorphism and DR risk among T2DM patients. The data was further analyzed in fixed/random effect models using RevMan 5.3 under five genetic models. Results: Six studies comprising 2,132 subjects from four distinct ethnicities were included. The present study revealed that MnSOD gene polymorphism was associated with a significantly increasing DR risk in T2DM patients under the co-dominant model (VV vs. AA) (OR 1.87 [1.42, 2.46], p<0.0001) and dominant model (VV+AV vs. AA) (OR 1.85 [1.02, 3.33], p=0.0400). Conclusions: T2DM individuals with rs4880 VV alleles are more susceptible to DR development, making them as a potential marker for heightened DR susceptibility in T2DM patients, laying the foundation for a gene panel to assess their susceptibility to develop DR.
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Nugrahani et al. (2024) conducted a meta-analysis in Diabetic retinopathy in type 2 diabetes mellitus (n=2,132). MnSOD Ala16Val gene polymorphism (VV genotype) vs. AA genotype was evaluated on Risk of diabetic retinopathy (co-dominant model VV vs. AA) (OR 1.87, 95% CI 1.42, 2.46, p=<0.0001). The MnSOD Ala16Val gene polymorphism (VV vs. AA) significantly increased the risk of diabetic retinopathy in patients with type 2 diabetes (OR 1.87).
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