Why the study?
Does race affect blood pressure response to ACE inhibitors in children?
Does race affect blood pressure response to ACE inhibitors in children?
Answers are grounded in this paper and cite their sources.
Racial effects on pediatric ACE inhibitor BP response remain unclarified; leaves open race-specific dosing needs.
Angiotensin-converting enzyme (ACE) inhibitors are frequently used to treat hypertension in children.(1) ACE inhibitors alter the balance between the vasoconstrictive, salt-retentive, and cardiac hypertrophic properties of angiotensin II and the vasodilatory and natriuretic properties of bradykinin; they also alter the metabolism of other vasoactive substances.(2) Through these mechanisms, ACE inhibitors decrease systemic vascular resistance and promote natriuresis without increasing heart rate. This study evaluated the results of six trials of ACE inhibitors in children, using meta-analytic techniques to estimate the effect of race on blood pressure response.
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Li et al. (2008) studied this question.
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