Left ventricular diastolic dysfunction limits use of maximum systolic elastance as an index of contractile function.
Why the study?
Does maximum systolic elastance (Emax) accurately reflect left ventricular contractile dysfunction in the presence of diastolic dysfunction in canine hearts?
Population
27 canine hearts in an isolated blood-perfused heart apparatus
Comparison
60 or 90 minutes of global ischemia followed by… vs Baseline measurements before ischemia-reperfusion
Design
Preclinical
Follow-up
90 minutes of reperfusion
Authors
Discussion
Loading...
Member takes
Implication
Emax may fail to detect contractile dysfunction amid diastolic impairment after ischemia; leaves open its reliability as sole contractility index.
Structured PICO
Does maximum systolic elastance (Emax) accurately reflect left ventricular contractile dysfunction in the presence of diastolic dysfunction in canine hearts?
P
Population
27 canine hearts in an isolated blood-perfused heart apparatus (14 normal hearts, 13 with pressure-overload hypertrophy)
I
Intervention
60 or 90 minutes of global ischemia followed by 90 minutes of reperfusion
C
Comparator
Baseline measurements before ischemia-reperfusion
O
Outcome
Maximum systolic elastance (Emax) and left ventricular diastolic pressuresurrogate
Maximum systolic elastance (Emax) may fail to accurately detect declines in left ventricular contractile function when concurrent diastolic dysfunction is present.
Cite This Study
Zile et al. (1991) studied this question.