Tolerance of the hypertrophic heart to ischemia. Studies in compensated and failing dog hearts with pressure overload hypertrophy.
Population
25 dogs
Comparison
60 minutes of global ischemia followed by 90… vs Comparison between normal control dogs, dogs…
Design
Preclinical
Follow-up
1 year after banding
Authors
Discussion
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Member takes
Implication
Compensated LVH preserves ischemia tolerance in canines; leaves open translation to human LVH.
Structured PICO
P
Population
25 dogs (10 normal controls, 15 with left ventricular hypertrophy induced by aortic banding at 8 weeks of age, studied 1 year later; 10 with LVH compensation and 5 with LVH failure)
I
Intervention
60 minutes of global ischemia (37 degrees C) followed by 90 minutes of reperfusion in an isolated blood-perfused heart apparatus
C
Comparator
Comparison between normal control dogs, dogs with compensated LVH, and dogs with LVH failure
O
Outcome
Tolerance to ischemia (measured by diastolic pressure, myocardial ATP, lactate washout, and developed pressures)surrogate
Compensated left ventricular hypertrophy in a canine model does not impair tolerance to global ischemia, whereas failing hypertrophic hearts show increased diastolic pressure and impaired recovery.
Cite This Study
Gaasch et al. (1990) studied this question.