Key result
Aortic banding in dogs led to a progressive decline in circumferential fiber shortening in those with pump failure (29%) compared to controls (38%, p<0.05) at 12 months.
Population
16 conscious dogs with aortic bands placed at 8 weeks of age and 5 littermate controls.
Comparison
Aortic banding at 8 weeks of age to induce… vs 5 littermate controls
Design
Preclinical
Follow-up
12 months
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Characterizes decompensation in canine pressure-overload model; leaves open translation to human heart failure phenotypes.
Absolute Event Rate: 29% vs 38%
p-value: p=<0.05
In a canine model of pressure-overload hypertrophy, the transition to pump failure is characterized by a progressive decline in myocardial shortening and elevated left ventricular end-diastolic pressure.
A 1989 study studied Pressure-overload hypertrophy (n=21). Aortic banding vs. Littermate controls was evaluated on Circumferential fiber shortening at 12 months (p=<0.05). Aortic banding in dogs led to a progressive decline in circumferential fiber shortening in those with pump failure (29%) compared to controls (38%, p<0.05) at 12 months.
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