Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
August 1, 1962BloodOpen Access

Studies on the Nature of the Circulating Anticoagulant Directed against Antihemophilic Factor: With Notes on an Assay for Antihemophilic Factor

View Full Paper
Ask AI
Bookmark
Share

Population

In vitro plasma and serum samples containing circulating anticoagulant directed against antihemophilic factor

Design

Preclinical

Authors

RBRobert T. BreckenridgeRochester General HospitalOROscar D. RatnoffAmerican Heart Association

Discussion

Loading...

Member takes

Implication

Suggests enzymatic antihemophilic factor inactivation in animal models; leaves open relevance to human inhibitor development.

Structured PICO

P
Population
In vitro plasma and serum samples containing circulating anticoagulant directed against antihemophilic factor
I
Intervention
Investigation of the kinetics and characteristics of the anticoagulant-antihemophilic reaction using a modified kaolin clotting time assay
O
Outcome
Nature, mode of action, and kinetics of the circulating anticoagulant

The study characterizes a circulating anticoagulant against antihemophilic factor, providing evidence that its mechanism of inactivation is likely enzymatic rather than an antigen-antibody reaction.

Cite This Study

Breckenridge et al. (1962) studied this question.

synapsesocial.com/papers/6a1d8a987328fa9a742fa6f7https://doi.org/10.1182/blood.v20.2.137.137

Topics

Anticoagulation in AF
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1REFRACTORINESS IN HEMOPHILIA TO COAGULATION-PROMOTING AGENTS: WHOLE BLOOD AND PLASMA DERIVATIVES1950 · 32 citations
  2. 2THE KAOLIN CLOTTING TIME1958 · 144 citations
  3. 3STUDIES ON THE ACTION OF HAGEMAN FACTOR: EVIDENCE THAT ACTIVATED HAGEMAN FACTOR IN TURN ACTIVATES PLASMA THROMBOPLASTIN ANTECEDENT*1961 · 208 citations