A New Theory of Interference With the Clotting Mechanism: The Complexing of Euglobulin With Factor V, Factor Vii and Prothrombin

Article1 August 1958A NEW THEORY OF INTERFERENCE WITH THE CLOTTING MECHANISM: THE COMPLEXING OF EUGLOBULIN WITH FACTOR V, FACTOR VII AND PROTHROMBINHENRY H. HENSTELL, M.D., MIRIAM KLIGERMAN, B.S.HENRY H. HENSTELL, M.D.Search for more papers by this author, MIRIAM KLIGERMAN, B.S.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-49-2-371 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptINTRODUCTIONA new theory of interference with the clotting mechanism was recently advanced by the authors, based on the observation that unusual plasma globulins complex with and/or coprecipitate clotting factors.12, 13The consequence is a reduction or inactivation of clotting factors, resulting in hemorrhagic disorders of varying degree. In addition, an unstable clotting mechanism and/or increased local concentrations of clotting factors would result, causing an increased thrombotic tendency. This theory offers a reasonable explanation for bleeding diatheses such as occur in purpura hyperglobulinemica, macroglobulinemia, multiple myeloma, liver damage and other conditions characterized by production of unusual plasma globulins. It can...Bibliography1. AnderssonSamuelson BA: A case of hyperglobulinemia with profound eye changes and acrocyanosis, Acta med. Scandinav. 117: 248-260, 1944. CrossrefGoogle Scholar2. BraunsteinerFalknerNeumayerPakesch HRAF: Makromoleculare Kryoglobulinämie, Klin. Wchnschr. 32: 722-726, 1954. CrossrefMedlineGoogle Scholar3. Case Record #43031 of the Massachusetts General Hospital, New England J. Med. 256: 134-138, 1957. CrossrefMedlineGoogle Scholar4. 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Author, Article, and Disclosure InformationAffiliations: Los Angeles, California*Received for publication August 14, 1957.From the Institute for Medical Research, Cedars of Lebanon Hospital, and the Department of Medicine, University of Southern California School of Medicine, Los Angeles, California.†Aided by a grant from the Leukemia Research Foundation, Inc., Los Angeles, California, and grant #H-2668 from the National Heart Institute, Department of Health, Education, and Welfare.Requests for reprints should be addressed to Henry H. Henstell, M.D., Institute for Medical Research, Cedars of Lebanon Hospital, 4751 Fountain Avenue, Los Angeles 29, California. 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LEE, M.D., GIOVANNI RACCUGLIA, M.D.Quantitative and Qualitative Changes in Fibrinogen Following Major Surgical OperationsGLOBULINS AND BLOOD-CLOTTINGSIX CHILDREN WITH COUGHSUNUSUAL DISLOCATION OF THE PATELLACryofibrinogenemiaCryoglobulinemiaMultiple myelomaPlasma-Cell MyelomaMACROGLOBULINS AND MACROGLOBULINAMIAHyperglobulinæmic Thrombo-Hæmorrhagic Diathesis 1 August 1958Volume 49, Issue 2Page: 371-387KeywordsAttentionBlood plasmaGlobulinsHeartHemorrhageHospital medicineLiverMultiple myelomaProteinsThrombosis Issue Published: 1 August 1958 PDF DownloadLoading ...