AN ABNORMAL PROTEIN which precipitated when cooled and returned to solution at room temperature was found in the plasma of a man who had migrating thrombophlebitis and pulmonary neoplasia. Thrombophlebitis migrans had been present for 11 months before the diagnosis of lung neoplasm was established. The phenomenon of a cryoprotein has not been previously described in connection with thrombophlebitis migrans and neoplasm. For this reason, it is believed the following case report and experiments with some details of the cryoprotein are of interest.
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Korst et al. (1955) studied this question.
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