Cryoglobulinemia. I. Report of Two Cases With Discussion of Clinical Manifestations, Incidence and Significance

Article1 January 1950CRYOGLOBULINEMIA. I. REPORT OF TWO CASES WITH DISCUSSION OF CLINICAL MANIFESTATIONS, INCIDENCE AND SIGNIFICANCEDAVID P. BARR, M.D., F.A.C.P., GEORGE G. READER, M.D., CHARLES H. WHEELER, M.D.DAVID P. BARR, M.D., F.A.C.P., GEORGE G. READER, M.D., CHARLES H. WHEELER, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-32-1-6 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe term, cryoglobulinemia, was proposed by Lerner and Watson28in 1947 in describing a patient whose serum contained a cold precipitable protein and whose presenting symptom was an extensive purpura that developed when he was exposed to the cold. They suggested that the designation of cryoglobulin be applied to any one of a group of proteins with the common property of precipitating or gelifying from cooled serum and that it include those proteins which in high concentration may precipitate at room temperature. Interest in the case of purpura led Lerner, Barnum and Watson26to a search for similar proteins in...Bibliography1. AdamsAllingLawrence WSELJS: Multiple myeloma—its clinical and laboratory diagnosis with emphasis on electrophoretic abnormalities, Am. J. Med. 6: 141, 1949. CrossrefMedlineGoogle Scholar2. AndersonSamuelson BA: A case of hyperglobulinemia with pronounced eye changes and acrocyanosis, Acta. med. Scandinav. 117: 248, 1944. CrossrefGoogle Scholar3. Apitz K: Die Paraproteinosen. Über die Störung des Eiweiss Stoffwechsels bei Plasmocytom, Virchow's Arch. f. path. Anat. 306: 631, 1940. CrossrefGoogle Scholar4. BayrdHeck EDFJ: Multiple myeloma—a review of 83 proven cases, J. A. M. A. 133: 147, 1947. 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Y.*Presented at the Thirtieth Annual Session of the American College of Physicians, New York, N. Y., March 29, 1949.From the Department of Medicine of the New York Hospital-Cornell University Medical Center. 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HOWELL, M.D.PROTEINS IN MULTIPLE MYELOMAOBSERVATION AND INTERPRETATIONCRYOGLOBULINÆMIASymmetrical peripheral gangrene complicating pulmonary embolism�ber die Aminos�urezusammensetzung der Bence-Jones ProteineDie Elektrophorese bei inneren KrankheitenCase 37081 1 January 1950Volume 32, Issue 1Page: 6-29KeywordsAttentionProteinsSerum proteinsTemperature ePublished: 1 December 2008 Issue Published: 1 January 1950 PDF downloadLoading ...