Why the study?
Does KB-R7943 alter normal excitation-contraction coupling or prevent Ca2+ overload in rat ventricular myocytes?
Does KB-R7943 alter normal excitation-contraction coupling or prevent Ca2+ overload in rat ventricular myocytes?
Selective blockade of Ca2+ influx via NCX with KB-R7943 prevents arrhythmogenic Ca2+ overload without impairing normal excitation-contraction coupling or glycoside inotropy in rat ventricular myocytes.
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May prevent Ca2+ overload arrhythmias without impairing contractility in myocytes; extends preclinical NCX data but leaves clinical translation open.
Satoh et al. (2000) studied this question.
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