Key result
Exercise training increased survival in a rodent model of salt-sensitive hypertension, with an approximate 30% increase in mean days survived (P<0.02).
Why the study?
Does low-intensity exercise training improve survival in a rodent model of salt-sensitive hypertension?
Population
13 male, inbred Dahl salt-sensitive rats arriving at 8 weeks of age, fed a high-salt diet after a 1-week…
Comparison
Exercise training consisting of running 20… vs Sedentary control group.
Design
Preclinical, randomly divided
Authors
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Does not support clinical adoption; leaves open translation of survival benefits from rodent salt-sensitive hypertension models.
RCT (n=13)
Randomly divided
Does low-intensity exercise training improve survival in a rodent model of salt-sensitive hypertension?
Effect estimate: 30% increase in mean days survived
p-value: p=<0.02
Low-intensity exercise training significantly improves survival in a rodent model of salt-sensitive hypertension, independent of blood pressure lowering effects.
Libonati et al. (2006) conducted an RCT in Salt-sensitive hypertension (n=13). Exercise training vs. Sedentary control was evaluated on Survival (30% increase in mean days survived, p=<0.02). Exercise training increased survival in a rodent model of salt-sensitive hypertension, with an approximate 30% increase in mean days survived (P<0.02).
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