What does this research mean for the field?

Daily administration of 150 mg of aspirin does not significantly alter the trajectories of pregnancy-associated plasma protein A (PAPP-A) or placental growth factor (PlGF) in women at increased risk of preterm preeclampsia. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

December 25, 2023American Journal of Obstetrics and GynecologyOpen Access

Aspirin for evidence-based preeclampsia prevention trial: effects of aspirin on maternal serum pregnancy-associated plasma protein A and placental growth factor trajectories in pregnancy

View Full Paper

Ask AI

Bookmark

To explore how aspirin affects serum pregnancy-associated plasma protein A and placental growth factor in high-risk pregnant women.
798 women randomly assigned to aspirin 150 mg, 822 to placebo daily from before 14 to 36 weeks gestation
Biomarkers measured at baseline and follow-ups at 19-24, 32-34, and 36 weeks
Generalized additive mixed models analyzed treatment effects by gestational age.
Pregnancy-associated plasma protein A levels increased over time, while placental growth factor peaked at 32 weeks then declined.
Biomarker values consistently below 1.0 multiple of the median indicated a high-risk population.
No significant difference in biomarker trajectories between aspirin and placebo groups (P values: .259 and .335).

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Randomized trial investigates aspirin's impact on biomarker trajectories in women at risk of preterm preeclampsia, highlighting no significant effects.

Cite This Study

Rolnik et al. (2023) studied this question.

synapsesocial.com/papers/6a1d918b73c56dd1bd2fda20 https://doi.org/10.1016/j.ajog.2023.12.031

View Full Paper

Ask AI

Bookmark

Implication

Randomized trial investigates aspirin's impact on biomarker trajectories in women at risk of preterm preeclampsia, highlighting no significant effects.

Aspirin for evidence-based preeclampsia prevention trial: effects of aspirin on maternal serum pregnancy-associated plasma protein A and placental growth factor trajectories in pregnancy

Key Points

Discussion

Implication

Cite This Study

Aspirin for evidence-based preeclampsia prevention trial: effects of aspirin on maternal serum pregnancy-associated plasma protein A and placental growth factor trajectories in pregnancy

Key Points

Discussion

Implication

Cite This Study

Also Consider

Also Consider