Antiretroviral-Drug Resistance among Patients Recently Infected with HIV
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Overview
Epidemiological analysis reveals transmitted antiretroviral drug resistance in newly infected individuals, highlighting critical challenges for standard frontline therapy regimens.
Key Points
- To assess the prevalence and epidemiological impact of transmitted antiretroviral drug resistance among individuals newly infected with human immunodeficiency virus.
- Assessed baseline drug resistance profiles across cohorts of individuals recently diagnosed with acute or recent HIV infection.
- Evaluated surveillance and clinical data from North American transmission settings.
- The prevalence of transmitted resistance to antiretroviral drugs among newly infected individuals is estimated at 1% to 11%.
- Transmitted resistance variants compromise standard first-line antiretroviral treatment options prior to therapeutic exposure.
Cite This Study
Little et al. (2002) studied this question.