What does this research mean for the field?

Helicobacter pylori screen-and-treat strategies maximize population benefits for gastric cancer prevention when performed before age 40, particularly in high-risk racial groups. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

This study aims to identify the optimal age for H. pylori screening to prevent gastric cancer in high-risk populations.

May 1, 2025HelicobacterOpen Access

The Optimal Age of Helicobacter pylori Screen‐and‐Treat for Gastric Cancer Prevention in the United States

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Authors

DMDuco T. MülderErasmus MC JOJames F. O’MahonyUniversity College Dublin DSDianqin SunErasmus MC

Discussion

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Implication

Randomized trial suggests early H. pylori screening improves gastric cancer prevention in high-risk groups.

Key Points

This study aims to identify the optimal age for H. pylori screening to prevent gastric cancer in high-risk populations.
Developed a microsimulation model (MISCAN-gastric) calibrated to SEER incidence data.
Compared one-time screen-and-treat ages 20-65 to no screening regarding cumulative incidence reduction, NNS, and NNT.
Focused on high-risk non-Hispanic Black males and compared to other racial subgroups.
Without screening, 332 noncardia gastric cancer cases occurred in 100,000 non-Hispanic Black males.
Screen-and-treat at age 20 reduced incidence by 43%, whereas age 65 only reduced it by 5%.
NNS was lowest at age 30 (563), while NNT was highest at age 65 (3681) and lowest at age 20 (261).

Cite This Study

Mülder et al. (2025) studied this question.

synapsesocial.com/papers/6a1d9c057328fa9a742fc045 https://doi.org/10.1111/hel.70039

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The Optimal Age of Helicobacter pylori Screen‐and‐Treat for Gastric Cancer Prevention in the United States

Discussion

Member takes

Implication

Key Points

Cite This Study

The Optimal Age of Helicobacter pylori Screen‐and‐Treat for Gastric Cancer Prevention in the United States

Discussion

Member takes

Implication

Key Points

Cite This Study

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