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The aim is to investigate the role of CCR2 and CCR5 variations in HIV-1 infection and AIDS progression.

August 15, 1997Science

Contrasting Genetic Influence of CCR2 and CCR5 Variants on HIV-1 Infection and Disease Progression

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The aim is to investigate the role of CCR2 and CCR5 variations in HIV-1 infection and AIDS progression.
Genetic association analysis conducted on five AIDS cohorts totaling 3003 patients.
Assessment of the influence of CCR2-64I mutation on AIDS progression.
Comparison of effects between CCR2-64I and CCR5-Delta32 mutations.
CCR2-64I does not influence HIV-1 infection incidence but delays AIDS progression by 2 to 4 years.
38 to 45 percent of rapid AIDS progressors have either CCR2-+/+ or CCR5-+/+ genotype.
28 to 29 percent of long-term survivors possess a mutant genotype for CCR2 or CCR5.

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Genetic association analysis reveals CCR2-64I delays AIDS onset in HIV-1-infected individuals.

Smith et al. (1997) studied this question.

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