Key result
Patients with young-onset hypertension had significantly higher mean pulse wave velocity (11.22 vs 7.36 m/s, P < 0.001) and elevated levels of IL-6 and MCP-1 compared to normotensive controls.
Why the study?
Cytokines and aortic stiffness may play roles in arterial hypertension, but their relationship and involvement in the etiology of young-onset hypertension remained to be explored.
Are inflammation markers and aortic stiffness increased in patients with young-onset hypertension compared to normotensive controls?
Case-Control (n=32)
No
Are inflammation markers and aortic stiffness increased in patients with young-onset hypertension compared to normotensive controls?
Young-onset hypertension is associated with increased aortic stiffness and elevated inflammatory markers (IL-6 and MCP-1), suggesting inflammation plays a role in its etiology.
Suggests inflammation contributes to young-onset hypertension; hypothesis-generating and should not yet change practice.
Background/aim: Young-onset hypertension is a form of condition diagnosed in patients aged below 40. Cytokines such as interleukin (IL)-6 and also MCP-1 may play a role in the development of arterial hypertension. Aortic stiffness can be detected by measuring pulse wave velocity (PWV). We aimed to explore the relationship between inflammation and aortic stiffness and investigate their roles in the etiology of young-onset hypertension. Materials and methods: We enrolled 16 patients diagnosed with young-onset hypertension and 16 volunteers without hypertension. The plasma levels of MCP-1 and IL-6 were determined using an enzyme-linked immunosorbent assay and quantitative enzyme-linked immunoassay, respectively. Carotid-femoral PWV was measured using an arteriograph device. Results: Compared with those in normotensive controls, the plasma levels of IL-6 and MCP-1 and the PWV values were significantly higher in patients with young-onset hypertension (P < 0.001). PWV values were also positively correlated with the levels of MCP-1 and IL-6. However, no statistically significant difference was noted in intima-media thickness between the two groups (P = 0.224). Conclusion: In this study, increased PWVs and the levels of inflammation markers were associated with aortic stiffness and inflammation in patients with young-onset hypertension, suggesting they have a role in the etiology of hypertension.
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Gökaslan et al. (2019) conducted a case-control in Young-onset hypertension (n=32). Young-onset hypertension vs. Normotensive controls was evaluated on Mean carotid-femoral pulse wave velocity (PWV) (p=<0.001). Patients with young-onset hypertension had significantly higher mean pulse wave velocity (11.22 vs 7.36 m/s, P < 0.001) and elevated levels of IL-6 and MCP-1 compared to normotensive controls.
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