Key result
Optical coherence tomography revealed that uncovered struts were significantly more frequent in thrombosed compared with nonthrombosed regions (ratio of percentages 8.26; 95% CI 6.82-10.04; P<0.001).
Why the study?
What are the underlying pathomechanisms of very late drug-eluting stent thrombosis as assessed by optical coherence tomography?
Observational (n=64)
Yes
What are the underlying pathomechanisms of very late drug-eluting stent thrombosis as assessed by optical coherence tomography?
Effect estimate: Ratio of percentages 8.26 (95% CI 6.82-10.04)
p-value: p=<0.001
Optical coherence tomography reveals that strut malapposition, neoatherosclerosis, uncovered struts, and stent underexpansion are the leading mechanisms of very late stent thrombosis in both early- and newer-generation drug-eluting stents.
No takes yet. Share an insight, caveat, or question.
Supports uncovered struts as a mechanism of very late thrombosis; hypothesis-generating for targeted interventions pending prospective trials.
Taniwaki et al. (2016) conducted an observational in Very late stent thrombosis (VLST) (n=64). Optical coherence tomography (OCT) vs. Nonthrombosed regions was evaluated on Frequency of uncovered struts in thrombosed compared with nonthrombosed regions (Ratio of percentages 8.26, 95% CI 6.82-10.04, p=<0.001). Optical coherence tomography revealed that uncovered struts were significantly more frequent in thrombosed compared with nonthrombosed regions (ratio of percentages 8.26; 95% CI 6.82-10.04; P<0.001).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: