What does this research mean for the field?

The region of dominant pacemaker activity in the canine sinoatrial node exhibits significantly greater densities of muscarinic cholinergic and beta1-adrenergic receptors compared to other sinoatrial node regions and adjacent atrial muscle. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

November 1, 1995Circulation Research

Relative Densities of Muscarinic Cholinergic and β-Adrenergic Receptors in the Canine Sinoatrial Node and Their Relation to Sites of Pacemaker Activity

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Population

Tissue sections containing the sinoatrial node (SAN) and adjacent right atrial muscle from 18 canine hearts

Comparison

Quantitative light-microscopic autoradiography… vs Atrial myocytes vs SAN cells; adjacent superior…

Design

Preclinical

Authors

SBScott L. BeauArkansas Heart Hospital DHDwight HandUniversity of Cincinnati RSRichard B. SchuesslerElectrophysiology

Discussion

Member takes

Implication

May inform SAN autonomic models in animals; leaves open human translation and clinical relevance.

Structured PICO

Population

Tissue sections containing the sinoatrial node (SAN) and adjacent right atrial muscle from 18 canine hearts

Intervention

Quantitative light-microscopic autoradiography of radioligand binding sites and in vitro mapping

Comparator

Atrial myocytes vs SAN cells; adjacent superior and inferior SAN regions vs dominant pacemaker region

Outcome

Spatial distribution and relative densities of muscarinic cholinergic and beta-adrenergic receptorssurrogate

The canine sinoatrial node has significantly higher densities of muscarinic cholinergic and beta1-adrenergic receptors compared to atrial myocytes, with the highest densities localized to the dominant pacemaker region.

Cite This Study

Beau et al. (1995) studied this question.

synapsesocial.com/papers/6a1dc152cd67cee37334cd2c https://doi.org/10.1161/01.res.77.5.957

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Relative Densities of Muscarinic Cholinergic and β-Adrenergic Receptors in the Canine Sinoatrial Node and Their Relation to Sites of Pacemaker Activity

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Relative Densities of Muscarinic Cholinergic and β-Adrenergic Receptors in the Canine Sinoatrial Node and Their Relation to Sites of Pacemaker Activity

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider