Key result
Neutrophil count and neutrophil/lymphocyte ratio were significantly higher in STEMI patients compared to non-STEMI and unstable angina patients with coronary collateral development (p<0.001).
Why the study?
Inflammation-related markers provide diagnostic and prognostic information for CAD and ACS, but the comparison of neutrophil count and NLR across different types of ACS with coronary collateral development needed evaluation.
Observational (n=426)
In patients with acute coronary syndrome and coronary collateral development, inflammatory markers (neutrophil count and NLR) are significantly higher in STEMI compared to non-STEMI and unstable angina.
Higher neutrophil count and NLR may mark greater inflammation in STEMI despite collaterals; hypothesis-generating and requires prospective validation before clinical use.
OBJECTIVE Inflammation-related markers provide diagnostic and prognostic information for coronary artery disease and acute coronary syndrome. We aimed to compare neutrophil count and neutrophil/lymphocyte ratio (NLR) in acute coronary syndrome patients with coronary collateral development in our study. METHODS A total of 426 patients (102 unstable angina pectoris (USAP), 223 non-ST-elevation myocardial infarction (non-STEMI), 103 ST-elevation myocardial infarction (STEMI) were compared regarding hemoglobin, platelet, lymphocyte, neutrophil count, and NLR. RESULTS Neutrophil count and NLR were significantly lower in USAP patients and higher in STEMI patients; 5.14± 1.79 vs. 7.21± 3.05 vs. 9.93±4.67 and 2.92±2.39 vs. 5.19±4.80 vs. 7.93±6.38, p <0.001. Other parameters, i.e., hemoglobin, platelet, and lymphocyte count, were not significantly different between the groups. CONCLUSIONS In our study, it was concluded that there may be a statistically significant difference in the number of neutrophil counts and NLR among the types of acute coronary syndromes with coronary collateral development.
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Mansıroğlu et al. (2020) conducted an observational in Acute coronary syndrome with coronary collateral development (n=426). Acute coronary syndrome type (STEMI vs non-STEMI vs USAP) was evaluated on Neutrophil count and neutrophil/lymphocyte ratio (NLR) (p=<0.001). Neutrophil count and neutrophil/lymphocyte ratio were significantly higher in STEMI patients compared to non-STEMI and unstable angina patients with coronary collateral development (p<0.001).
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