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February 15, 2018International Journal of Advances in MedicineOpen Access

Association between neutrophil to lymphocyte ratio and severity of coronary artery disease

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Key result

Elevated NLR is linked to ~51% higher odds of abnormal coronary angiography and greater CAD severity.

  • OR 1.514
  • 95% CI 1.145-2.002
  • P=0.004
  • n=324

Why the study?

Neutrophil-to-lymphocyte ratio (NLR) is a systemic inflammatory marker correlated with poor cardiovascular outcomes, but its association with severity of coronary atherosclerosis needed investigation.

Does neutrophil-to-lymphocyte ratio correlate with the presence and severity of coronary artery disease in patients undergoing coronary angiography?

Population

324 patients undergoing coronary angiography

Comparison

Patients with abnormal coronary angiography vs patients with normal coronary angiography

Design

Cross-sectional study

Authors

HJH. R. JagadishMDM. DivyaprakashRMR. Manjunath

Discussion

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Overview

Supports NLR-CAD association in angiography patients; leaves open prospective validation before clinical use.

Study Design

Type

Cross-Sectional (n=324)

Multicenter

No

Structured PICO

Does neutrophil-to-lymphocyte ratio correlate with the presence and severity of coronary artery disease in patients undergoing coronary angiography?

P
Population
324 patients undergoing coronary angiography for suspected or known coronary atherosclerosis were evaluated in a cross-sectional study to determine the association between neutrophil-to-lymphocyte ratio and disease severity.
E
Exposure
Neutrophil-to-lymphocyte ratio (NLR) calculated from venous blood samples collected before coronary angiography
C
Comparator
Patients with normal coronary angiography (control group)
O
Outcome
Presence of coronary artery disease (defined as ≥50% stenosis in any main coronary artery) and severity of coronary atherosclerosis determined by Gensini scoresurrogate

Main Result

Odds Ratio: 1.514 (95% CI 1.145–2.002)

p-value: p=0.004

Limitations

  • Limited number of study participants
  • Single-center study
  • Cross-sectional study design
  • Atherosclerosis evaluated only by coronary angiography which does not provide extensive information about coronary plaque burden
  • Cannot establish cause or effect relationship between NLR and atherosclerosis
  • limited number of study participants
  • participants were from 1 center rather than multiple centers
  • cross-sectional study design
  • evaluated atherosclerosis only by coronary angiography (lumen only, no extensive information about coronary plaque burden)
  • provides no information regarding cause or effect relationship between NLR and atherosclerosis

Cite This Study

Jagadish et al. (2018) conducted a cross-sectional in Coronary artery disease (n=324). Neutrophil-to-lymphocyte ratio vs. Normal coronary angiography was evaluated on Abnormal coronary angiography (OR 1.514, 95% CI 1.145-2.002, p=0.004). An elevated neutrophil-to-lymphocyte ratio was an independent predictor of abnormal coronary angiography (OR 1.514) and significantly correlated with the severity of coronary artery disease.

synapsesocial.com/papers/6aa903d2022accd6d12c8dcbhttps://doi.org/10.18203/2349-3933.ijam20180493
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Association between neutrophil to lymphocyte ratio with the severity of coronary artery diseases2023 · 1 citations
  2. 2Association between Neutrophil to Lymphocyte Ratio and Severity of Coronary Artery Disease in Chronic Stable Angina2018 · 4 citations
  3. 3Relation of neutrophil-to-lymphocyte ratio with coronary artery disease severity in patients undergoing coronary angiography2022
  4. 4Relation between neutrophil-to-lymphocyte ratio and severity of coronary artery stenosis2014 · 38 citations
  5. 5Neutrophil to Lymphocyte Ratio and the Extent of Coronary Artery Disease2015 · 102 citations