Key result
A neutrophil-to-lymphocyte ratio cutoff of 2.385 predicted high Gensini scores (severe coronary artery stenosis) with a sensitivity of 64% and specificity of 63%.
Why the study?
Does the neutrophil-to-lymphocyte ratio correlate with the severity of coronary artery stenosis in patients with coronary artery disease?
Observational (n=219)
Does the neutrophil-to-lymphocyte ratio correlate with the severity of coronary artery stenosis in patients with coronary artery disease?
The neutrophil-to-lymphocyte ratio is an independent predictor of coronary artery stenosis severity and may serve as a useful, easily accessible biomarker in coronary heart disease.
Answers are grounded in this paper and cite their sources.
May correlate with CAD severity; leaves open clinical utility pending prospective validation.
This study aimed to investigate the relation between the neutrophil-to-lymphocyte ratio (NLR) and the severity of coronary artery stenosis. A total of 219 patients were included in the study, comprising 51 coronary artery atherosclerosis (CAC) patients, 92 stable angina pectoris (SAP) patients, and 76 acute coronary syndrome (ACS) patients. Based on the results of coronary angiography, all patients were divided into two groups according to the Gensini scores: the low-score group (N = 142) and the high-score group (N = 77). The NLR was computed from the ratio of neutrophils and lymphocytes from the complete blood count. The association between the NLR and severity of coronary artery disease was assessed using correlation analysis and logistic regression. The NLR was higher in ACS patients than in SAP and CAC patients (P < 0.05). In addition, the NLR was higher in the high-score group than in the low-score group (P < 0.05). Correlation analysis showed that the NLR was significantly correlated with the Gensini score. After multivariate analysis, high NLRs were independent predictors of high Gensini scores, together with age and high-density lipoprotein. A cutoff NLR of 2.385 predicted high Gensini scores with a sensitivity and specificity of 64 and 63%, respectively. The study suggests that the NLR is an independent predictor of coronary heart disease that may be useful for predicting the severity of coronary artery stenosis.
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Zhang et al. (2014) conducted an observational in Coronary artery stenosis (n=219). Neutrophil-to-lymphocyte ratio (NLR) was evaluated on High Gensini score (severity of coronary artery stenosis) (p=<0.05). A neutrophil-to-lymphocyte ratio cutoff of 2.385 predicted high Gensini scores (severe coronary artery stenosis) with a sensitivity of 64% and specificity of 63%.
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