Key result
NLR over 3 predicts ~17-fold higher odds of severe CAD.
Why the study?
Neutrophil-to-lymphocyte ratio (NLR) has emerged as a new inflammatory marker for identifying coronary artery disease (CAD), but its correlation with CAD severity and suitable predictive cut-off values were not established.
Does neutrophil-to-lymphocyte ratio correlate with coronary artery disease severity in patients undergoing coronary angiography?
Population
147 patients undergoing coronary angiography for angina with ischemic ECG changes
Comparison
NLR levels across low, intermediate, and high SYNTAX score groups
Design
Cross-sectional study
Authors
Loading...
NLR >3 may flag severe CAD on angiography; leaves open incremental value in prospective risk models.
Cross-Sectional (n=147)
No
Does neutrophil-to-lymphocyte ratio correlate with coronary artery disease severity in patients undergoing coronary angiography?
Odds Ratio: 17.36 (95% CI 6.77–44.49)
p-value: p=0.001
An elevated neutrophil-to-lymphocyte ratio (>3) is strongly associated with high SYNTAX scores and may serve as a simple, accessible biomarker for predicting severe coronary artery disease.
Nepal et al. (2022) conducted a cross-sectional in Coronary artery disease severity (n=147). Neutrophil-to-lymphocyte ratio (NLR) > 3 vs. Lower NLR was evaluated on High SYNTAX score (>32) (OR 17.36, 95% CI 6.77-44.49, p=0.001). A neutrophil-to-lymphocyte ratio greater than 3 independently predicted severe coronary artery disease, defined as a high SYNTAX score, with an odds ratio of 17.36.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: