Key result
Higher NLR moderately predicts high SYNTAX score complexity in stable CAD.
Cross-Sectional
Effect estimate: AUC 0.72 (95% CI 0.65-0.80)
p-value: p=< .001
Demonstrates that an elevated neutrophil to lymphocyte ratio correlates with severe coronary artery disease in stable angina, suggesting its utility as a systemic inflammatory marker.
OBJECTIVES: We examined the association between neutrophil to lymphocyte ratio (NLR) and the complexity of coronary artery disease assessed by SYNTAX score (SS). METHODS: The study population included patients with chest pain who had undergone coronary angiography for stable angina pectoris. Patients were classified depending on whether the SS was 0 or SS > 0. RESULTS: Left ventricular ejection fraction, estimated glomerular filtration rate, and NLR were found to be the independent predictors of high SS in multivariate analysis. The area under the receiver-operating curve of NLR was 0.72 (0.65-0.80, P < .001) for predicting high SS. The optimal cutoff value of NLR to predict high SS was 2.7 (sensitivity of 72% and a specificity of 61%). There was a significant correlation between NLR ratio and continuous SS (r = .552, P < .001). CONCLUSION: The NLR is a readily measurable systemic inflammatory marker and is associated with both the presence and the complexity of coronary artery disease.
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Kaya et al. (2013) conducted a cross-sectional in Stable coronary artery disease. Neutrophil to lymphocyte ratio (NLR) was evaluated on Complexity of coronary artery disease assessed by high SYNTAX score (SS > 0) (AUC 0.72, 95% CI 0.65-0.80, p=< .001). Neutrophil to lymphocyte ratio (NLR) significantly predicted high SYNTAX score complexity in patients with stable coronary artery disease (AUC 0.72; 95% CI 0.65-0.80; P < .001).
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