Key result
High neutrophil to lymphocyte ratio (>2.59) was an independent predictor of high residual SYNTAX score in patients with STEMI (OR 3.933; 95% CI 2.419-6.393; P<.001).
Why the study?
The neutrophil to lymphocyte ratio predicts adverse clinical outcomes in several cardiovascular diseases, but its association with residual SYNTAX score in patients with STEMI undergoing primary PCI required investigation.
Does a high neutrophil to lymphocyte ratio predict increased residual SYNTAX score in patients with STEMI undergoing primary PCI?
Observational (n=613)
Does a high neutrophil to lymphocyte ratio predict increased residual SYNTAX score in patients with STEMI undergoing primary PCI?
Odds Ratio: 3.933 (95% CI 2.419–6.393)
Absolute Event Rate: 31% vs 9.7%
p-value: p=<.001
A higher neutrophil to lymphocyte ratio is an independent predictor of increased residual SYNTAX score in STEMI patients undergoing primary PCI, suggesting its utility as a simple biomarker for residual coronary artery disease severity.
High NLR may flag greater residual CAD burden in STEMI; leaves open added value for risk stratification or management.
The neutrophil to lymphocyte ratio (NLR) predicts adverse clinical outcomes in several cardiovascular diseases. Our aim was to investigate the association of residual SYNTAX score (rSS) with the NLR in patients (n = 613) with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention. Patients were divided into 2 groups: group 1 with low NLR (<2.59) and group 2 with high NLR (>2.59). Coronary artery disease severity was calculated for both groups besides baseline clinical and demographic variables. Receiver operating characteristic curve analysis demonstrated that NLR with a cutoff value of 2.59 had good predictive value for increased rSS (area under the curve = 0.707, 95% CI: 0.661-0.752, P < .001). The median rSS value of group 2 was higher (2.0 [0-6.0]; 4.0 [0-10.0], P < .001) compared with group 1; the number of patients with high rSS was also higher in group 2 (26 [9.7%]; 107 [31.0%], P < .001). In multivariate logistic regression analysis, the NLR (odds ratio = 3.933; 95% CI: 2.419-6.393; P < .001) was an independent predictor of high rSS. Additionally, there was a positive correlation between NLR and rSS (r = 0.216, P < .001). In conclusion, higher NLR was an independent predictor of increased rSS in patients with STEMI.
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Kahraman et al. (2020) conducted an observational in ST-segment elevation myocardial infarction (STEMI) (n=613). High neutrophil to lymphocyte ratio (NLR >2.59) vs. Low neutrophil to lymphocyte ratio (NLR <2.59) was evaluated on High residual SYNTAX score (rSS) (OR 3.933, 95% CI 2.419-6.393, p=<.001). High neutrophil to lymphocyte ratio (>2.59) was an independent predictor of high residual SYNTAX score in patients with STEMI (OR 3.933; 95% CI 2.419-6.393; P<.001).
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